Compatible Stability of Cyclophosphamide and Mesna Admixture for Injection in 4 Commonly Used Infusions
- VernacularTitle:环磷酰胺与美司钠配伍在4种常用输液中的稳定性考察
- Author:
Hui WANG
;
Chao DONG
;
Jia HAN
;
Li LI
;
Laicheng WANG
- Keywords:
Cyclophosphamide;
Mesna;
Infusion;
Compatible;
Stability;
HPLC
- From:
China Pharmacist
2017;20(7):1331-1333
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the compatible stability of cyclophosphamide (CTX) and Mesna admixture for injection in 4 commonly used infusions (5% glucose injection,0.9% sodium chloride injection,fructose injection and xylitol injection) at different temperatures.Methods: An HPLC method was adopted to determine the contents of CTX for injection in 24h respectively under 5℃ and 25℃.The appearance and pH value of the admixture were investigated.Results: No significant changes of appearance, pH value or content of the admixture were found out in 24h under 5℃ and 25℃.Conclusion: CTX and Mesna admixture for injection is compatible with the 4 commonly used infusions under 5℃ and 25℃ for clinical use in 24 h.
