Phenylboronic acid-based glucose-responsive materials: synthesis and applications in insulin delivery
10.11665/j.issn.1000-5048.20170302
- VernacularTitle:苯硼酸类糖敏感材料在胰岛素控释系统中的应用
- Author:
Dan LI
;
Mian FU
;
Hai QIAN
;
Wenlong HUANG
- Keywords:
phenylboronic acid;
glucose-sensitive;
insulin;
delivery systen
- From:
Journal of China Pharmaceutical University
2017;48(3):259-267
- CountryChina
- Language:Chinese
-
Abstract:
Glucose-sensitive materials have attracted much interest due to their potential application in diabetes treatment in recent years.Phenylboronic acid-based glucose-responsive polymers,which possess continuous glucose sensitivity and good stability,have been most widely used in self-regulated insulin delivery.This review covers the recent advances in PBA-functionalized nanogels (microgels),micelles,vesicles and nanoparticles.Synthesis and application of these nanomaterials are discussed.With the development of PBA-regulated polymers,these nanomaterials will migrate from laboratory to clinical use in the near future.
