Various dosage forms of nimodipine:application and research advances
10.13220/j.cnki.jipr.2017.06.010
- VernacularTitle:尼莫地平各类剂型的应用和研发进展
- Author:
Cuicui LIN
;
Zihua XIA
;
Fan YANG
- Keywords:
antihypertensive agents;
nimodipine;
dosage forms;
marketing analysis;
clinical application
- From:
Journal of International Pharmaceutical Research
2017;44(6):518-521
- CountryChina
- Language:Chinese
-
Abstract:
Nimodipine is the second generation of dihydropyridine Ca2+ antagonist. The scope of its clinical application has been expanded because of the excellent curative effects on cerebrovascular diseases. Nimodipine is commonly available on the market as oral or injection preparation,which has to be given several times per day. It may induce peripheral cholinergia side effects and has low bioavailability. Therefore,it is necessary to develop novel drug formulation with optimized delivery system. In the present review, an attempt is made to discuss the current progress of nimodipine in pharmaceutics,including the difference of market situation,safety and efficacy of different dosage forms. Meanwhile,the main research directions of new dosage forms are summarized,which can pro-vide reference for developing more efficient and convenient nimodipine preparations.
