Analysis on clinical effect of clopidogrel hydrogen sulfate plus nimodipine in treating transient cerebral ischemic attack
10.3969/j.issn.1671-8348.2017.20.013
- VernacularTitle:氢氯吡格雷联合尼膜同治疗短暂性脑缺血发作的临床效果分析
- Author:
Chengke LI
;
Qin HE
;
Fei QIAO
;
Anhui FU
;
Hui TANG
- Keywords:
clopidogrel hydrogen sulfate;
nimodipine;
ischemic attack,transient
- From:
Chongqing Medicine
2017;46(20):2777-2779
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of clopidogrel hydrogen sulfate plus nimodipine in treating transient cerebral ischemic attack.Methods A total of 159 outpatients and inpatients with transient cerebral ischemic attack in the neurosurgery department and the neurology outpatient department of our hospital from January 1,2012 to September 1,2016 were divided into 3 groups.The group A(43 cases) orally took clopidogrel hydrogen sulfate plus aspirin;the group B (51 cases) treated with oral clopidogrel hydrogen sulfate plus nimodipine;the group C(65 cases) was treated with clopidogrel hydrogen sulfate plus nimotop.The curative effects were observed in 3 groups.The differences of PT.APTT,FIB and PLT in 3 groups were compared between before and after treatment.Results The total effective rate of the group A and C was significantly better than that of the group B(P<0.05),the curative effect had no statistical difference between the group A and C (P>0.05);the effect of the group B and group C on coagulation was superior to that of the group A(P<0.05).The three group had no severe bleeding events(cerebral bleeding,etc.),the difference was statistically significant.Conclusion Clopidogrel hydrogen sulfate combined with nimotop can significantly reduce the frequency of transient cerebral ischemic attack,has little influence on the coagulation indicators,and is safe and effective.
