Analysis on correlation between vessel cancer embolus with prognosis in patients with colorectal cancer
10.3969/j.issn.1671-8348.2017.20.018
- VernacularTitle:结直肠癌患者脉管癌栓与预后的相关性分析
- Author:
Jianming CUI
;
Fanhong LI
;
Teng CHENG
- Keywords:
colorectal neoplasms;
vessel cancer embolus;
KRAS gene;
prognosis
- From:
Chongqing Medicine
2017;46(20):2791-2792,2796
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between vessel cancer embolus with other clinicopathological features and tumor tissue KRAS gene mutation in the patients with colorectal cancer and its significance to colorectal cancer prognosis.Methods The postoperative clinicopathological data in 182 patients with colorectal cancer during 2011-2014 were retrospectively analyzed and the patients were followed up.Results Forty-five cases showed vessel cancer embolus positive of colorectal cancer,which had the rrelationship with the lymph node metastasis,pathological differentiation degree,liver metastasis,nerve infiltration and increase of CEA and CA199 levels,while had no relationship with the age,sex,tumor size,infiltration depth and pathological type.The 3-year survival rate was 51.1% in the vessel cancer embolus positive group,which was significantly lower than 61.3% in the negative group (P<0.05).However,the 3-year survival rate had no statistically significant difference between the vessel cancer embolus positive complicating KRAS gene mutation group and the vessel cancer embolus positive group(P>0.05).Conclusion Vessel cancer embolus decreases the 3-year survival rate and affects the prognosis in the patients with colorectal cancer.The survival rate in complicating KRAS gene mutation is similar.
