Efficacy and safety of tranexamic acid for treating perioperative bleeding during PFNA internal fixation in elderly femoral intertrochanteric fracture
10.3969/j.issn.1671-8348.2017.20.020
- VernacularTitle:氨甲环酸对老年股骨粗隆间骨折患者行PFNA内固定手术围术期失血的有效性及安全性研究
- Author:
Yun ZHU
;
Gang ZHAO
;
Sining LI
;
Xiaobing HE
- Keywords:
tranexamic acid;
intertrochanteric fracture;
proximal femoral nail anti-rotation
- From:
Chongqing Medicine
2017;46(20):2797-2799
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of preoperative intravenous drip of tranexamic acid(TXA) on perioperative bleeding in proximal femoral nail anti-rotation(PFNA) operation of elderly intertrochanteric fracture.Methods A total of 115 elderly patient with intertrochanteric fracture undergoing PFNA internal fixation were selected and divided into the treatment group(58 cases) and control group (57 cases).The treatment group was intravenously dripped with 20mg/kg TXA before operation,while the control group had no special treatment.Hemoglobin (Hb) and hematocrit(Hct) were recorded before operation and on postoperative 1,3 d.The total amounts of perioperative blood loss were calculated by using the Gross equation and Nadler equation.The blood transfusion rate and thromboembolic complications occurrence situation in the two groups were performed the statistics.Results The total amounts of perioperative blood loss were (872.21±312.53) mL in the treatment group and (1 162.41±368.64) mL in the control group,the difference was statistically significant(P<0.01).The blood transfusion rate was 3.45% in the treatment group and 17.5% in the control group,the difference was statistically significant (P<0.01).No deep vein thrombosis and pulmonary embolism occurred in both groups.The occurrence rate of venous thrombus was 5.1% in the treatment group and 7.0% in the control group without statistical difference(P>0.05).Conclusion Preoperatively intravenous drip of 20mg/kg TXA in PFNA internal fixation of elderly intertrochanteric fracture can effectively decrease perioperative blood loss without increasing the risk of thrombus formation.
