Effect of NQO1 and NQO2 expression in clinical prognosis of ovarian carcinoma

VernacularTitle:NQO1和NQO2的表达在卵巢癌临床预后中的作用
Author: Li LI ; Guoping XIONG ; Danni GONG ; Qinghua ZHANG
Keywords: quinone oxidoreductase 1; quinone oxidoreductase 2; ovarian neoplasms; prognosis
From: Chongqing Medicine 2017;46(21):2945-2946,2951
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of quinone oxidoreductase 1 (NQO1) and quinone oxidoreductase 2 (NQO2) expression in the prognosis of ovarian carcinoma.Methods The two online databases were used to perform the online analysis on the NQO1 and NQO2 mRNA levels and prognosis of ovarian cancer patients,1 306 cases of ovarian cancer were performed the Kaplan-Meier analysis by using the KaplanMeier plotter (K-M plotter);578 cases of ovarian cancer in the TCGA database were performed the univariate COX regression survival analysis.Results The K-M plotter analysis showed that the NQO1 expression level had no obvious correlation with the prognosis of ovarian cancer (P>0.05),the higher the NQO2 level,the better the prognosis (HR=0.83,P=0.006 2).The COX regression survival analysis showed that the NQO1 expression level had no obvious correlation with the prognosis of ovarian cancer(P>0.05),the higher the NQO2 level,the better the prognosis (P=0.038 29).Conclusion NQO2 expression level has no obvious correlation with the prognosis of ovarian cancer,moreover the higher the NQO2 expression level,the better the clinical prognosis of ovarian cancer.