Abnormal liver regeneration of T-cell-deficient mice after partial hepatectomy
10.7644/j.issn.1674-9960.2017.06.004
- VernacularTitle:T细胞缺陷裸小鼠部分肝切除肝再生异常
- Author:
Daxin LEI
;
Wenjing BU
;
Xian LIU
;
Xiaozhu MENG
;
Hui CHEN
;
Yiqun ZHAN
;
Xiaoming YANG
;
Miao YU
- Keywords:
T-lymphocytes;
hepatectomy;
liver regeneration;
gene expression;
proliferating cell nuclear antigen;
nude mice;
liver injury
- From:Military Medical Sciences
2017;41(6):424-429
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the regulation of T cells in the process of liver regeneration using a model of mice after 70% liver resection.Methods We performed 70% hepatectomy in T-cell-deficient mice and control mice.The liver mass and body mass ratio, BrdU infiltration level, proliferating cell nuclear antigen (PCNA),expression of M phase marker protein p-HDAC3, and serum transaminase levels were measured.Results The recovery of liver mass and body mass ratio of thymus-deficient mice occurred significantly later than that of control mice.The peak time of BrdU infiltration levels and the expression of PCNA and p-HDAC3 in T-cell-deficient mice were later than in control mice, but the degree of liver injury was lower.Conclusion T cells are involved in the regulation of liver regeneration, and the absence of T cells delays the process of liver regeneration.
