Significance of AKR1C3 for esophageal cancer patients under radiotherapy
10.7644/j.issn.1674-9960.2017.06.019
- VernacularTitle:AKR1C3在放疗食管癌患者病理标本检测中的意义
- Author:
Jing ZHAO
;
Wei XIONG
;
Demin ZHOU
;
Xianshu GAO
;
Jun REN
- Keywords:
esophageal neoplasms;
radiotherapy;
AKR1C3
- From:
Military Medical Sciences
2017;41(6):494-497
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the significance of the expression level of aldo-keto reductase family 1 member C3(AKR1C3) for esophageal carcinoma patients treated with radiotherapy.Methods The clinical data of 28 patients with locally advanced esophageal carcinoma treated with radiotherapy alone was retrospectively analyzed, and the expression level of AKR1C3 was detected by immunohistochemistry.Statistical analysis was performed using SAS 8 statistical software, P<0.05 was considered statistically significant difference.Results The expression level of AKR1C3 was different in esophageal carcinoma patients at different levels of differentiation.The level of AKR1C3 expression was negatively correlated with efficacy of radiotherapy (P=0.031, 95%CI 0.151-0.914).Conclusion AKR1C3 can serve as a promising biomarker of the efficacy of radiotherapy for esophageal cancer.
