Advance in research on regulation of sRNAs in bacterial biofilm formation
10.7644/j.issn.1674-9960.2017.06.027
- VernacularTitle:小RNA对细菌生物膜形成的调控研究进展
- Author:
Xiaofang GAO
;
Zizhong LIU
;
Wenliang LI
;
Ruifu YANG
;
Yanping HAN
- Keywords:
sRNA;
biofilm;
c-di-GMP
- From:Military Medical Sciences
2017;41(6):530-533,542
- CountryChina
- Language:Chinese
-
Abstract:
Small RNAs(sRNAs) play a significant role in the regulation of bacterial growth.When sensing certain environmental cues such as fluctuation of nutrient concentration, temperature, pH, and osmolarity, sRNAs can influence the expression of target genes.The formation of biofilms is initiated by bacteria transitioning from the planktonic to the surface-associated mode of growth, which is a self-produced extracellular matrix composed of proteins, polysaccharides, and DNA.Recent evidences have shown that small RNA plays an important role in the regulation of bacterial biofilm formation.sRNAs have key roles in biofilm formation process by base pairing with target mRNAs or interaction with modulating proteins.This review discussed the regulation mechanism and pathway of sRNAs in bacterial biofilms formation, and summarized three classical regulatory models of sRNAs in bacterial biofilms formation, this review also gives the research status and development direction of sRNAs in bacterial biofilms formation.
