Pharmacodynamics of Baijin Granules on model rats with sequelae of pelvic inflammatory disease
10.3969/j.issn.1001-1528.2017.07.001
- VernacularTitle:白金颗粒对盆腔炎性疾病后遗症模型大鼠的药效学
- Author:
Cao LIANG
;
Zhiping WANG
;
Fang LI
;
Yan HUANG
;
Meilin YE
;
Qiao FENG
;
Bo ZHANG
- Keywords:
Baijin Granules;
sequelae of pelvic inflammatory disease;
hemorheology;
blood routine;
pathological morphology
- From:
Chinese Traditional Patent Medicine
2017;39(7):1329-1335
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the pharmacodynamics of Baijin Granules [Mallotus apelta (lour.) Muell.Arg.,Smilax china L.],Zhuang medicine,on model rats with sequelae of pelvic inflammatory disease.METHODS The rat model for sequelae of pelvic inflammatory disease was built with mixed bacteria (Escherichia coli and Staphylococcus aureus) and mechanical injury.Subsequently,the rats were randomly divided into eight groups,including model,Baijin Granules low-,middle-,high-dose,positive control (dexamethasone and Huahong Granules),blank control and sham operation groups,with ten rats in each group.After 14 days of successive administration,the hemorheology and blood routine in rats' abdominal aorta were measured by collecting blood in 24 hours of last administration.The pathological morphology of uterine tissue was observed.RESULTS The hemorheology indexes,WBC count and neutrophil percentage were significantly decreased in the model rats,and the pathological morphology of uterine tissue was markedly improved.CONCLUSION Baijin Granules have good therapeutic effects on sequelae of pelvic inflammatory disease in rats.
