Roles of cytokines and three-dimensional printing technology in skeletal muscle repair
10.3969/j.issn.2095-4344.2017.20.020
- VernacularTitle:细胞因子及细胞打印技术与骨骼肌损伤修复
- Author:
Kangkang WANG
- From:
Chinese Journal of Tissue Engineering Research
2017;21(20):3241-3247
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND: The regeneration ability of skeletal muscle is limited, and cytokines play an important role in skeletal muscle repair. A variety of cells and regulatory molecules are involved in skeletal muscle repair. Three-dimensional (3D) printing technique is an advanced technology used to construct an in vitro multicellular system with biological activity and has aroused widely attention in skeletal muscle repair.OBJECTIVE: To investigate the role of proinflammatory cytokines and cell growth factors in skeletal muscle repair, and to summarize the advantages and application of 3D printing technology in skeletal muscle repair. METHODS: A computer-based retrieval of PubMed and WanFang databases was conducted for the articles addressing the roles of cytokines and application of 3D printing technique in skeletal muscle injury published from 2002 to 2015. Totally 146 articles were searched firstly, and finally 45 eligible articles were enrolled in accordance with the inclusion and exclusion criteria.RESULTS AND CONCLUSION: Proinflammatory cytokines, such as tumor necrosis factor-α, interleukin-1β, interleukin-6, and anti-inflammatory cytokines, such as interleukin-10, interleukin-4, play a critical role in skeletal muscle repair. Cell growth factors such as insulin-like growth factor, fibroblast growth factor, transforming growth factor can effectively promote the proliferation of myoblasts and cell differentiation into myotubes, further promoting the proliferation of skeleton satellite cells. Additionally, these cytokines act mutually, which is of great significance for skeletal muscle repair. 3D printing technology can quickly and accurately reproduce and reconstruct the complex structure of target tissues or organs, so it has been extensively applied in toxicology research, medical testing and basic experiments. The role of 3D printing technology in skeletal muscle repair will be a hotspot in the future.
