Comparison and improvement of the methods for establishment of rat models of myocardial ischemia
10.3969.j.issn.1671-7856.2017.07.018
- VernacularTitle:大鼠心肌缺血模型制备方法的比较及改进浅析
- Author:
Shitian ZHANG
;
Lulu PANG
;
Hanqing TANG
;
Cenhan HUANG
- Keywords:
Coronary heart disease;
Myocardial ischemia;
Animal model;
Establishment methods;
Heart;
Surgery
- From:
Chinese Journal of Comparative Medicine
2017;27(7):98-101
- CountryChina
- Language:Chinese
-
Abstract:
The method for preparation of models of myocardial ischemia in rats have been well described in the literature, are of practical value and have been chosen by many researchers for pharmacological studies of drugs for human diseases.However, there is still lack in some details of their operability and practicability.We re-selected the coronary artery ligation site, simplified the procedures and improved the experimental method for preparation of the models, and made satisfactory result.In this paper we will review the selection of method for preparing myocardial ischemia model in rats, describe some details of the surgical operation, explored the influencing factors and so on, and provide a reference for selecting most appropriate animal model in research.
