Relationship Between Blood Big Endothelin Level and Contrast-induced Acute Kidney Injury in Patients With Emergent Percutaneous Coronary Intervention
10.3969/j.issn.1000-3614.2017.07.003
- VernacularTitle:行急诊经皮冠状动脉介入治疗患者血浆大内皮素水平与术后对比剂诱导急性肾损伤的相关性分析
- Author:
Ying YUAN
;
Yuan TIAN
;
Xiaoying HU
;
Tong LUO
;
Xiaojin GAO
;
Xueyan ZHAO
;
Jun ZHANG
;
Hong QIU
;
Yuan WU
;
Hongbing YAN
;
Shubin QIAO
;
Yuejin YANG
;
Runlin GAO
- Keywords:
Angioplasty;
transluminal;
percutaneous coronary;
Big endothelin;
Contrast-induced kidney injury
- From:
Chinese Circulation Journal
2017;32(7):633-637
- CountryChina
- Language:Chinese
-
Abstract:
To explore the relationship between blood level of big endothelin and contrast-induced acute kidney injury (CI-AKI) in patients with emergent percutaneous coronary intervention (PCI). Methods: A total of 1061 consecutive patients received emergent PCI in our hospital from 2013-01 to 2015-06 were enrolled. According to blood levels of big endothelin, the patients were divided into 2 groups: Normal big endothelin group, n=236 and Elevated big endothelin group, n=825. The baseline condition, procedural features, occurrence rate of CI-AKI and composite endpoint events at 6 and 12 months post-operation were studied which including nonfatal myocardial infarction, revascularization, stroke and all-cause death. The risk factors for CI-AKI occurrence were identified by Logistic analysis. Results: The overall occurrence rate of CI-AKI was 22.7% (241/1061). Compared with Normal big endothelin group, Elevated big endothelin group had the higher incidence of CI-AKI, increased composite endpoint events at 6 and 12 months post-operation with P=0.041, P=0.040 and P=0.021, respectively. With adjusted covariates, elevated blood level of big endothelin, no matter as a continuous variable or categorical variable had the enhanced risk of CI-AKI incidence in patients after emergent PCI. Conclusion: Elevated blood level of big endothelin may significantly increase the risk of CI-AKI in patients with emergent PCI.
