Effect of acute normovolemic hemodilution combinded with enhanced recovery after surgery on immune function in patients undergoing hepatic lobectomy
10.3969/j.issn.1006-5725.2017.14.016
- VernacularTitle:急性等容血液稀释联合快速康复外科措施对肝叶切除术患者免疫功能的影响
- Author:
Qiaoling ZHOU
;
Hongzhen LIU
;
Xiaohong LAI
;
Meijuan LIAO
;
Hua LIANG
;
Weiming OU
;
Huiping WU
;
Huanwei CHEN
;
Feiwen DENG
- Keywords:
acute normovolemic hemodilution;
enhanced recovery after surgery;
hepatic lobectomy;
immune function
- From:
The Journal of Practical Medicine
2017;33(14):2315-2318
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of acute normovolemic hemodilution(ANH)combined with enhanced recovery after surgery(ERAS)on immune function in patients undergoing hepatic lobectomy. Methods 80 patients were divided into two groups:ERAS group(group E),ANH combined with ERAS group(group AE). bleeding volume,blood transfusion,infused fluid volume,urine output during operation and clinical index after surgery were recorded. Exhaust and defecation time ,fluid intake time and hospitalization duration were also record-ed. Blood samples were obtained from the patients at 30 min before anesthesia induction(T1),immediately(T2), 24 h(T3),3 d(T4)and 7 d(T5)after the end of operation for determination of the expression of CD3+,CD4+, CD8+ on T cells and natural killer cell. Results In group E ,CD3+,CD4+ T-lymphocytes and NK cells at T2-3 decreased as compared with T0. Compared with group E ,no allogeneic blood transfusion cases were found and clinical index duration was shorter in group AE. CD3+,CD4+T-lymphocytes and NK cells at T2-3 increased in group AE as compared with those in Group E. The difference is significant (P < 0.05). Conclusion ANH combined with ERAS can decrease allogenic blood transfusion and increase post-operation immunologic function ,shorten the postoperative hospitalization time.
