Goserelin protects ovarian function of premenopausal women with breast cancer
10.3969/j.issn.1006-5725.2017.14.029
- VernacularTitle:戈舍瑞林对绝经前乳腺癌患者卵巢功能的保护作用
- Author:
Lilan FANG
;
Gengsheng YU
;
Xiaoping LI
;
Xiuxin LIN
;
Wenjing DENG
;
Ying ZHOU
- Keywords:
breast neoplasm;
chemotherapy;
goserelin;
ovary function
- From:
The Journal of Practical Medicine
2017;33(14):2361-2364
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Goserelin in protection of the ovarian function of pre-menopausal breast cancer patients. Methods Eighty premenopausal patients with breast cancer randomly divided equally into study group and control group. The two groups were compared in terms of the menstrual status and the levels of E2,FSH,LH before and after chemotherapy. Results The menstrual recovery rates of the study group and the control group were 90% and 57.5%,respectively ,with statistically significant difference between them (P = 0.018). In the study group,the serum E2 decreased gradually to the postmenopausal level,and the serum levels of FSH and LH were also significantly decreased during the treatment. While in the control group ,the E2 levels gradually decreased ,but the levels of FSH and LH significantly increased during the chemotherapy. Conclusions Goserelin can effectively prevent the injury of ovarian function caused by chemotherapy.
