Application of dexmedetomidine in cerebral aneurysm embolization in patients with hypertension

VernacularTitle:右美托咪定在高血压患者脑动脉瘤栓塞术中的应用
Author: Yaoxian ZHANG ; Xicheng LIU ; Qiuli ZHANG ; Zhanli LIU ; Wenyan WU
Keywords: dexmedetomidine; hypertension; cerebral aneurysm embolization
From: The Journal of Practical Medicine 2017;33(14):2365-2367
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of dexmedetomidine in cerebral aneurysm embolization in pa-tients with hypertension. Methods Sixty patients with hypertension undergoing emergency cerebral aneurysm em-bolization were randomly divided into two groups:research group(dexmedetomidine given group) and control group. SBP,DBP,HR,plasma norepinephrine(NE):baseline value(T0),before intubation(T1),after intubation (T2),after extubation(T3). Extubation time and anesthetic-related complications were also recorded. Results The hemodynamic parameters and plasma norepinephrine concentration in the research group were more stable than those in the control group at different time point during perioperative period. There was no difference between two groups about extubation time. The incidence of anesthetic-related complications in research group was lower than control group(P < 0.05). Conclusions Dexmedetomidine can reduce the stress response of intubation ,extuba-tion and perioperative hemodynamic fluctuations in cerebral aneurysm embolization in patients with hypertension. It can also reduce the consumption of prorofol and the incidences of adverse effects.