Expression and significance of Beclin 1 and LC3 in non small cell lung cancer
10.3969/j.issn.1006-5725.2017.13.007
- VernacularTitle:Beclin1和LC3蛋白在非小细胞肺癌的表达和临床意义
- Author:
Guilan DONG
;
Liang DONG
;
Chunjin KE
;
Yibing ZHANG
- Keywords:
non small lung cancer;
autophagy;
beclin1;
LC3
- From:
The Journal of Practical Medicine
2017;33(13):2097-2100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of beclin1 and LC3 in non small cell lung cancer and explore their clinical significance. Methods Immunohistochemistry was applied to confirm expression of Beclin1 and LC3 in 66 samples of NSCC and 52 samples of adjacent tissues. Clinical pathological features were analyzed. Results Beclin1 and LC3 expression were lower in cancer tissues than that in adjacent cancer tissues ,and the dif-ference was statistically significant(46.9%vs 75%,53%vs 80.7%,P<0.05). The expression of Beclin1 and LC3 was down-regulated with TNM staging rising and tissue differentiation decreasing. With tumor enlarging ,Beclin1 down-regulated,and the difference is statistically significant(P<0.05). Expression of Beclin1 was positively cor-related with LC3 expression(r=0.31,P<0.05). Conclusion The down-regulation of autophagy-related protein Beclinl and LC3 might be involved in the genesis and development of non small lung cancer.
