The clinical value of combined detection of five serum tumor markers in diagnosis of lung cancer
10.3969/j.issn.1673-4130.2017.14.005
- VernacularTitle:5项血清肿瘤标志物联合检测在肺癌诊断中的价值
- Author:
Jialing WU
;
Dan LUO
- Keywords:
lung cancer;
carcinoembryonic antigen;
neuron specific enolization enzyme;
21-1 non-small cell lung cancer associated antigen;
carbohydrate antigen 125
- From:
International Journal of Laboratory Medicine
2017;38(14):1885-1886,1889
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical value of serum carcinoembryonic antigen(CEA),neuron specific enolization enzyme(NSE),21-1 non-small cell lung cancer associated antigen(CYFRA21-1),carbohydrate antigen 125(CA125) and ferritin(Fer) in the diagnosis of lung cancer.Methods The levels of CEA,NSE,CYFRA21-1,CA125 and Fer were measured by electrochemlium-inescence in 103 patients with lung cancer,32 patients with benign lung diseases and 40 healthy people.Results The serum levels of CEA,NSE,CYFRA21-1,CA125 and Fer in patients with lung cancer[(110.2±95.5)ng/mL,(50.6±43.4)ng/mL,(32.8±29.5)ng/L,(122.7±110.4)U/L,(854.6±497.2)ng/mL] were significantly higher than those in patients with benign lung diseases and those in healthy people(t=6.21,5.71,6.75,6.62,7.74,P<0.05;t=5.26,4.86,5.81,5.20,6.26,P<0.05).The sensitivity values of CEA,NSE,CYFRA21-1,CA125,Fer and the combined determination containing five tumor markers were 39.81%,24.27%,71.84%,68.93%,77.66% respectively.The sensitivity and specificity of the combined determination containing five tumormarkers were 96.12%,95.00%.Conclusion The joint detection in the diagnosis of lung cancer could improve the sensitivity significantly,to help for early diagnosis of lung cancer,which is value to widely applied in clinic.
