Analysis on value of combined detection of Hcy,hs-CRP and Lp-PLA2 in diagnosis of ischemic cerebral stroke
10.3969/j.issn.1673-4130.2017.14.010
- VernacularTitle:缺血性脑卒中患者脂蛋白相关磷脂酶A2、同型半胱氨酸、高敏C反应蛋白联合检测的意义
- Author:
Meng DING
;
Yingwei WU
;
Shoujun XIE
;
Xueli GENG
;
Yaju WANG
- Keywords:
ischemic cerebral stroke;
homocysteine;
hypersensitive C-reactive protein;
lipoprotein-associated phospholipase A2
- From:
International Journal of Laboratory Medicine
2017;38(14):1898-1900
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the significance of levels and combined detection of plasma homocysteine(Hcy),high-sensitivity C reactive protein(hs-CRP) and lipoprotein-associated phospholipase A2(Lp-PLA2) in patients with ischemic cerebral stroke(ICS).Methods A total of 140 patients with ICS were selected into ICS group,and 100 healthy individuals were recruited in the control group.The plasma levels of Hcy,hs-CRP,Lp-PLA2 were examined,then the positive rates of them were statistically analyzed.Analyzed the value of the levels and joint detection of Hcy,hs-CRP and Lp-PLA2.Results The plasma levels and the positive rates of Hcy,hs-CRP and Lp-PLA2 in ICS group were statistically higher than those in the control group(P<0.05).The area under the receiver-operating characteristic curve of combined detection of Hcy,hs-CRP and Lp-PLA2 in diagnosis of ICS was 0.949,the sensitivity was 0.850,and the specificity was 0.807,which were higher than Hcy,hs-CRP and Lp-PLA2 alone.Conclusion The plasma levels of Hcy,hs-CRP and Lp-PLA2 increase in ICS patients,and the combined detection of the three indicators might improve the early diagnostic value of ICS.
