Preliminary Study of Levosimendan on Patients With Severe Aortic Stenosis and Heart Failure
10.3969/j.issn.1000-3614.2017.07.008
- VernacularTitle:左西孟旦注射液应用于重度主动脉瓣狭窄合并心力衰竭患者的初步研究
- Author:
Zhenyan ZHAO
;
Guangyuan SONG
;
Wenjia ZHANG
;
Zheng ZHOU
;
Guannan NIU
;
Hao ZHANG
;
Qian ZHANG
;
Siyong TENG
;
Tong LUO
;
Yuejin YANG
;
Yongjian WU
- Keywords:
Heart failure;
Aortic stenosis;
Levosimendan
- From:
Chinese Circulation Journal
2017;32(7):655-659
- CountryChina
- Language:Chinese
-
Abstract:
To explore the safety and efficacy of levosimendan in treating the patients with severe aortic stenosis and to analyze the cardial function before and after medication in order to guide clinical treatment. Methods: A total of 20 patients admitted in our hospital from 2014-01 to 2015-12 were enrolled with the standard of echocardiography confirmed severe aortic stenosis, left ventricular ejection fraction (LVEF)≤45%, NYHA III-IV and inefficacy for conventional anti-heart failure drug therapy. The patients received intravenous infusion of levosimendan at 0.1μg/(kg·min) by persistent pumping for 24 hours. Echocardiography, LVEF, dyspnea condition, NYHA grading and plasma levels of NT-proBNP were recorded pre- and post-medication to compare the cardiac function and symptoms of levosimendan therapy. Results: After levosimendan treatment, NYHA grade was improved, P=0.025 and NT-proBNP was reduced (9101.6±7368.0) pg/mLvs (13776.5±9503.7) pg/mL, P=0.018. The following parameters were similar before and after levosimendan therapy: LVEF (31.1±7.5)% vs (33.1±8.5)%, P=0.078, the average heart rate (79.6±13.8) bmp vs (82.8±9.5)bmp, P=0.200 and systolic blood pressure (99.6±11.7) mmHg vs (97.2±12.1) mmHg, P=0.071. There were 40% (8/20) patients with obviously improved and 50% (10/20) with improved dyspnea symptoms after levosimendan treatment. Conclusion: Our preliminary study presented that levosimendan could improve NYHA grading, remit dyspnea symptom and reduce blood NT-proBNP level in patients with severe aortic stenosis and heart failure; it had safety and tolerability at certain degree in clinical practice.
