Observation of the effectiveness of butylphthalide and naloxone in the treatment of elderly patients with cerebral hemorrhage
10.3760/cma.j.issn.1008-6315.2017.07.006
- VernacularTitle:丁苯酞联合纳洛酮治疗老年脑出血患者的效果观察
- Author:
Qingqiang QIAN
;
Bin LIU
;
Yibin CAO
- Keywords:
Butylphthalide;
Naloxone;
The elderly;
Cerebral hemorrhage
- From:
Clinical Medicine of China
2017;33(7):599-602
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of butylphthalide combined with naloxone in the treatment of elderly patients with cerebral hemorrhage.Methods A total of one hundred and thirty elderly patients with cerebral hemorrhage were selected in North China University of Science and Technology Affiliated Hospital from December 2012 to December 2014,and were randomly divided into two groups,each group 65 cases.Naloxone was used in the control group,while the observation group adopted butylphthalide combined with naloxone in its treatment.The curative effects were compared between two groups.Results After treatment,homocysteine,C reactive protein,hypoxia inducible factor,neurological function defect score were all significantly decreased in two groups (P<0.05).Homocysteine,C reactive protein,hypoxia inducible factor and neurological function defect score in the observation group were much lower than those of the control group ((10.2±1.3) μmol/L vs.(14.0±1.8) μmol/L,(3.9±1.1) mg/L vs.(6.9±1.4) mg/L,(51.6±10.3) pg/ml vs.(82.5±17.6) pg/ml,(3.7±1.0) points vs.(4.4±0.9) points,t=7.134,10.692,9.078,4.892,P<0.05).The total effective rate in the observation group was significantly higher than that of the control group (98.5% vs.89.2%,χ2=4.795,P<0.05).Compared the complications in two groups,the differences were not statistically significant (P>0.05).Conclusion Butylphthalide combined with naloxone is effective in the treatment of elderly patients with cerebral hemorrhage,which can significantly improve their clinical signs and neurological function.
