Research progress of ANXA3 in neoplastic disease
10.3760/cma.j.issn.1008-6315.2017.07.024
- VernacularTitle:膜联蛋白A3与肿瘤性疾病最新研究进展
- Author:
Weiyong YU
;
Chenggong ZHANG
;
Jingdong HE
- Keywords:
ANXA3;
Tumor;
Metastasis;
Drug resistance
- From:
Clinical Medicine of China
2017;33(7):663-667
- CountryChina
- Language:Chinese
-
Abstract:
Objective Annexin A3 (ANXA3) is a member of the annexin family,As the existing studies suggest,ANXA3 is closely related to tumor genesis,development,invasion,metastasis and prognosis.ANXA3 is down-regulated in prostate and kidney cancer,but it is up-regulated in breast cancer,liver cancer and other tumors.ANXA3 is related to tumor size,staging,lymphatic metastasis and prognosis.Silencing ANXA3 expression can not only inhibit the proliferation and invasion of colorectal cancer and hepatocellular carcinoma cells,but also restrain the migration of breast cancer cells.ANXA3 may also be involved in the regulation and maintenance of hepatocellular stem cells through HIF1a / Notch and JNK signaling pathways.The current studies have shown that ANXA3 can serve as a potential biological marker of tumor diagnosis,prediction of chemotherapy sensitivity,and provide a new target for oncotherapy.
