Dexmedetomidine and midazolam in procedural sedation: a systematic review of efficacy and safety
10.13481/j.1671-587x.20170420
- VernacularTitle:右美托咪啶和咪达唑仑用于程序化镇静疗效和安全性的系统评价
- Author:
Xianfei DING
;
Bo YUAN
;
Zhentao XU
;
Shaohua ZHENG
;
Yan MA
;
Peina SHI
;
Tongwen SUN
- Keywords:
dexmedetomidine;
midazolam;
procedural sedation;
Jadad scale;
systematic review
- From:
Journal of Jilin University(Medicine Edition)
2017;43(4):762-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically review the efficacy and safety of dexmedetomidine and midazolam in procedural sedation. Methods: PubMed,EMBase,Cochrane Library,CNKI,CBM and WanFang databases were retrieved to collect the randomized controlled trials (RCT) about comparion of efficacy and safety between dexmedetomidine and midazolam in procedural sedation up to March, 2017. Based on the inclusion criteria, the data extraction and quality evaluation were performed, and then the systematic evaluation was carried out.The outcome measures for efficacy were the satisfaction scores and pain scores of the patients and clinicians;the outcome measures for safety comparison were hypotension, hypoxia, and circulatory and respiratory complications.Results:There were 14 RCT satisfied the inclusion criteria including 949 patients.Compared with midazolam group, the incidence of pain, delirium, and analgesia of the patients in dexmedetomidine group had significant differences (P<0.05);but the incidence of respiratory depression, low blood pressure had no significant differences (P>0.05).Conclusion:When the adult patients are sedated, dexmedetomidine can be used as an ideal alternative to midazolam sedation.
