The influence of CTP-OD1-HA and CTP-OD2-HA fusion peptides or combine with imatinib on proliferation of K562 cells
10.3969/j.issn.1673-4130.2017.14.002
- VernacularTitle:CTP-OD1-HA和CTP-OD2-HA融合肽或联合imatinib对K562细胞增殖的影响
- Author:
Heng XIAO
;
Yanbin REN
;
Zhiming YANG
;
Shujie ZHOU
;
Lei YIN
;
Zhimei QIN
;
Ling XU
;
Shouxia LI
- Keywords:
chronic myeloid leukemia;
fusion peptide;
cell proliferation;
BCR-ABL
- From:
International Journal of Laboratory Medicine
2017;38(14):1876-1878
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of CTP-OD1-HA and CTP-OD2-HA fusion peptides and combined with imatinib on proliferation of K562 cells.Methods K562 cells were treated with CTP-OD1-HA and CTP-OD2-HA peptides or together with imatinib.The proliferation of cells were detected and compared by MTT and clone formation methods.Results MTT examination demonstrated that CTP-OD1-HA and CTP-OD2-HA peptides could inhibit the proliferation of K562 cells,and the effect was more obvious when acted along with imatinib;Clone formation showed that CTP-OD1-HA and CTP-OD2-HA peptides suppressed the continuous colony forming ability of K562 cells.Conclusion CTP-OD1-HA and CTP-OD2-HA could specially inhibit the proliferation of K562 cells,and increase the sensitivity of imatinib.
