Relationship between serum interleukin-22 levels and allergens in patients with type Ⅰhypersensitivity diseases
10.3969/j.issn.1673-4130.2017.14.016
- VernacularTitle:Ⅰ型过敏患者血清白细胞介素-22水平与变应原关系的研究
- Author:
Hongyan SHEN
;
Zhan XU
;
Yuanyuan GAO
;
Feng JIANG
;
Lu LU
- Keywords:
interleukin-22;
allergen;
monosensitization;
polysensitization
- From:
International Journal of Laboratory Medicine
2017;38(14):1916-1917,1920
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate serum levels of interleukin(IL)-22 in typeⅠhypersensitivity disease patients with monosensitization and polysensitization,inhaled allergens and food allergens,and explore the correlation between IL-22 levels and allergens.Methods A total of 100 patients with typeⅠhypersensitivity disease and 30 normal controls were recruited in this study.Western blot and enzyme-linked immuno sorbent assay were used to detect 19 types of allergens′ specific IgE antibody and IL-22 concentrations,respectively.Results Serum level of IL-22 was positive correlated with the number of sensitized allergens(r=0.318,P=0.001).The levels of IL-22 in polysensitization patients,monosensitization patients and normal controls were 24.52(20.41,29.27),22.02(15.25,25.59),18.06(16.02,23.04)pg/mL respectively.IL-22 in polysensitization patients(n=42) were higher than those in monosensitization patients(n=58) and normal controls(U=867.500 and 229.000,P<0.05,respectively).Compared with the normal controls,the IL-22 level was also higher in monosensitization patients(U=608.000),the difference was significant(P<0.05).However,there was no significant difference on IL-22 between inhaled allergens patients(n=34) and food allergens patients(n=24)(t=0.082,P>0.05).Conclusion Serum level of IL-22 increases in type Ⅰhypersensitivity disease patients,was is positive correlated with the number of sensitized allergens.
