Relationship between serum levels of C reactive protein,adiponectin and severity ofdisease,joint function in patients with rheumatoid arthritis
10.3969/j.issn.1673-4130.2017.14.024
- VernacularTitle:类风湿关节炎患者血清中C反应蛋白、脂联素水平与患者病情严重程度及患者关节功能的关系
- Author:
Bangjun HUANG
;
Yumei GU
- Keywords:
rheumatoid arthritis;
C reactive protein;
adiponectin;
joint function
- From:
International Journal of Laboratory Medicine
2017;38(14):1940-1941,1944
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between serum levels of C reactive protein,adiponectin and severity of disease,joint function in patients with rheumatoid arthritis(RA).Methods A total of 85 cases of RA treated in our hospital from September 2014 to August 2016 were selected into the RA group,and 20 healthy persons were recruited into control group.The serum C reactive protein,adiponectin were detected,compared in the two groups,and to investigate the relationship between them with severity of disease,joint function of the patients.Results C reactive protein of RA patients was(23.63±5.36) pg/mL,which was significant higher than that of the control group,the adiponectin,the ratio of C reactive protein and adiponectin were(4.64±1.74)ng/mL,0.37±0.06 respectively,which were significant lower than those of the control group,the differences were statistically significant(P<0.05).RA patients with more serious joint injury and disease status,the adiponectin,the ratio of adiponectin and C reactive protien were more lower,the C reactive protien was more higher,the differences in different joint injury and disease status groups were significant(P<0.05).Logistic analysis showed that adiponectin(P=0.04),the ratio of adiponectin and C reactive protien(P=0.01) were independent risk factors of bone damage in RA patients.Conclusion Serum C reactive protein and adiponectin level were closely related to the severity of RA and joint function.
