Effects of ginkgo biloba extract on CRP and TNF-α in rats with chronic obstructive pulmonary disease
10.3969/j.issn.1006-5725.2017.12.010
- VernacularTitle:银杏叶提取物对慢性阻塞性肺疾病大鼠CRP、TNF-α的影响
- Author:
Wei LIANG
;
Hongmei YANG
;
Aiwu LIANG
;
Yibao YANG
;
Yuqing FENG
;
Pengfei ZHANG
;
Ruixiang LI
;
Yuping TAN
- Keywords:
Chronic obstructive pulmonary disease;
Ginkgo biloba extract;
CRP;
TNF-α
- From:
The Journal of Practical Medicine
2017;33(12):1936-1938
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of ginkgo biloba extract(GBE)on c-reactive protein(CRP) and tumor necrosis factor-α(TNF-α)in serum and alveolar lavage fluid(BALF)from rats with chronic obstructive pulmonary disease(COPD). Methods 90 rats were randomly divided into groups A,B,C,D,E and F. There were 15 rats in each group. The rat model of COPD were established in groups B,C,D,E and F. Groups C and D were given intraperitoneal injections with GBE from day l to day l4 and day 29 to day 42. Groups E and F weregiven intraperitoneal injections with erythromycin from day l to day l4 and day 29 to day 42. After the end of experi-ment ,the contents of CRP and TNF-α in serum and BALF were detected in all groups. Results The contents of CRP and TNF-α in the serum and the BALF were markedly lower in groups C,D,E and F than in group B (P<0.05);and the contents of CRP in the serum and the BALF and TNF-αin the BALF were lower in groups C, E and F than in group D(P<0.05). Conclusions GBE can inhibit the airway and systemic inflammatory response in COPD rats. Early intervention is more effective.
