Regulation of phenylephrine-induced cardiac fibrosis by ANGPTL4
10.3969/j.issn.1006-5725.2017.12.011
- VernacularTitle:ANGPTL4对苯肾上腺素诱导的心肌纤维化的调控
- Author:
Lijuan WANG
;
Chen LIU
;
Yuanwen. XU
- Keywords:
Cardiac fibrosis;
Phenylephrine;
ANGPTL4
- From:
The Journal of Practical Medicine
2017;33(12):1939-1942
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study how ANGPTL4 modulates phenylephrine(PE)-induced cardiac fibrosis. Methods PE was applied to induce cardiac fibrosis. The knockdown effect of ANGPTL4 under PE stimuli was confirmed by Western blot;the proliferation of cardiac fibroblast was detected by CCK-8;mRNA levels of Collagen 1(Col1)and connective tissue growth factor(CTGF)were detected by QPCR to investigate the regula-tion of cardiac fibrosis by ANGPTL4. Results PE induced the proliferation of cardiac fibroblast and the up-regula-tion of mRNA levels of Col1 and CTGF;ANGPTL4 knockdown deteriorated cardiac fibrosis,manifested by the up-regulation of Col1 and CTGF. Conclusion ANGPTL4 inhibits PE-induced cardiac fibrosis.
