The clinical significance of combined detection of NEDD9,P53 and Ki67 in early diagnosis and evaluating malignant degree of gastric carcinoma
10.3969/j.issn.1006-5725.2017.12.016
- VernacularTitle:NEDD9、Ki67、P53联合检测对胃癌的早期诊断和恶性程度评估的价值
- Author:
Na WANG
;
Xiaoyan XU
;
Hong SHEN
;
Sisen ZHANG
;
Lihua WU
;
Jinhua YANG
- Keywords:
Gastric carcinoma;
Earlydiagnosis;
NEDD9;
Ki67;
P53
- From:
The Journal of Practical Medicine
2017;33(12):1961-1965
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression level and related prognostic significance of protein NEDD9,Ki67,P53 in gastric carcinoma. Methods A total of 30 normal stomach tissues were used as control group. The expression level of NEDD9,P53,Ki67 in early gastric carcinoma of 54 cases and advanced gastric car-cinoma in 51 cases were detected by immunohistochemistry ,respectively. Results (1) The expression level of protein NEDD9,P53,Ki67 in normal stomach tissues,early gastric carcinoma and advanced gastric carcinoma were increased(P<0.05).(2)The expression level NEDD9 protein in gastric carcinoma was associated with the depth of invasion and the degree of differentiation(P < 0.05). The expression of protein Ki67 was associated with clinical staging and the depth of invasion(P<0.05). The expression of protein P53 was associated with degree of differentiation,the depth of invasion,lymph node metastasis and clinical staging(P<0.05).(3)NEDD9 protein expression has a positive correlation with Ki67. The difference has statistical significance(r = 0.216,P = 0.027). Conclusions The expression level of protein NEDD9 ,Ki67 ,P53 increased in normal stomach tissues ,early gastric carcinoma and advanced gastric carcinoma. The expression level were significantly higher in early gastric carcinoma. Combined detection of NEDD9 ,P53 ,Ki67facilitatesearlydiagnosis and malignant degree of gastric carcinoma.
