Role and mechanism of resveratrol in a rat model of complex regional pain syndrome type Ⅰ
10.3969/j.issn.1006-5725.2017.11.011
- VernacularTitle:白藜芦醇在复杂性区域疼痛综合征Ⅰ型大鼠模型中的作用及机制
- Author:
Chunyan GUO
;
Xiaole SHI
;
Qianyu LI
;
Yuzhu LIU
;
Rui WU
- Keywords:
Complex regional pain syndrome typeⅠ;
Resveratrol;
MIF;
ERK signaling pathway
- From:
The Journal of Practical Medicine
2017;33(11):1761-1764
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role and mechanism of resveratrol in a rat model of complex region-al pain syndrome type Ⅰ(CRPS1). Methods 50 male SD rats were divided into control group(group A),sham operation group(group B),model group 1(group C),model group 2(group D),and model group 3(group E). Groups A,B and C received 5%DMSO;group D received ISO-1 of 1 mg/(kg·d);and group E received resveratrol of 20 mg/(kg · d)for 14 days. Pain behaviors were assessed on days 0,7,and 14. Serum levels of MIF and TNF-αwere detected by ELISA. MIF ,total ERK1/2 and p-ERK1/2 in sciatic nerve were detected by Western blot. Re-sults On days 7 and 14 after treatment,resveratrol injection,similar to ISO-1,significantly improved the pain threshold;serum levels of MIF and TNF-α were significantly decreased;expressions of MIF ,total ERK1/2 and p-ERK1/2 in sciatic nerve were also decreased significantly in group E,which were significantly lower than group C (P < 0.05). Conclusions Resveratrol can significantly improve pain threshold ,decrease expressions of MIF and p-ERK1/2 in a rat model of CRPS1,which might be involved in the inhibition of ERK signaling pathway.
