Expression of Merlin protein in female cervical cancer of Han ,Tibetan and Hui nationalities in Qinghai
10.3969/j.issn.1006-5725.2017.11.015
- VernacularTitle:青海汉、藏、回族女性宫颈癌中Merlin蛋白的表达意义
- Author:
Xing YANG
;
Chunmei WEI
;
Jianqing ZHANG
;
Man ZHANG
- Keywords:
Cervical squamous cell carcinoma;
Merlin protein;
Immunohistochemistry;
Different ethnic groups
- From:
The Journal of Practical Medicine
2017;33(11):1778-1781
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of the Merlin protein in normal cervix and cervical can-cer of the Han,Tibetan and Hui nationalities in Qinghai. Methods Immunohisto-chemical staining was per-formed to detect the expression of Merlin in 108 cases of cervical carcinoma(40 cases of Han,38 cases of Tibetan and 30 cases of Hui nationality)and 107 cases of normal cervix(40 cases of Han,37 cases of Tibetan and 30 cas-es of Hui nationality). Results The positive expression rates of Merlin in normal cervix were 90.0%,91.9%and 86.7%respectively and those in cervical carcinoma were 17.5%,18.4%and 16.7%respectively. There was signifi-cantly statistical difference(P<0.05). However,there was no significant difference in the positive rates of Merlin between cervical carcinoma among different ethnic groups(P>0.05). The expression of Merlin was not correlated with age,FIGO stage,lymph metastasis and cell differentiation(P > 0.05)in cervical carcinoma of three ethnic groups. Conclusion The decrease or even deletion of Merlin may be involved in the development of cervical can-cer,and it plays an important role in cervical cancer. The expression of Merlin exerts no effect on the occurrence of cervical cancer and it is not associated with the clinical characteristics of the patients ,suggesting that it may not be involved in the invasion and metastasis of cervical cancer.
