Prognostic value of preoperative aspartate aminotransferase to platelet ratio index for hepatocellular carci-noma after radical surgical resection
10.3969/j.issn.1006-5725.2017.11.024
- VernacularTitle:术前天冬氨酸氨基转移酶血小板比值对肝细胞癌切除术预后的分析
- Author:
Zhaoguang CHEN
;
Hui REN
;
Jianbin ZHANG
;
Zhijie LI
;
Hongbo WANG
- Keywords:
Hepatocellular carcinoma;
Aspartate aminotransferase;
Platelet;
Hepatectomy;
Prognosis
- From:
The Journal of Practical Medicine
2017;33(11):1814-1818
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prognostic value of blood aspartate aminotransferase to platelet ratio index(APRI)in patients with hepatocellular carcinoma(HCC)after radical surgical resection. Methods A retro-spective cohort study was conducted to analyze 228 patients with HCC who underwent radical surgical resection. Patients were divided into low APRI group(APRI<1.62)and high APRI group(APRI≥1.62). Patients′clinical and demographic data and overall survival(OS)were statistically analyzed and multivariate analysis was performed to identify prognostic factors. Results APRI was closely related to preoperative serum ALT level,PLT level,the positivity of HBsAg,liver cirrhosis and portal vein tumor thrombus. OS of patients in low APRI group was signifi-cantly better when compared to those with an elevated APRI(P<0.01). Multivariate analysis indicated that preop-erative APRI,maximum size of tumor,number of tumor nodules,portal vein tumor thrombus,TNM and differenti-ation of tumors were independent prognostic factors for HCC(P<0.05). Conclusions Preoperative APRI≥1.62 is an independent prognostic factor of OS for patients with HCC after radical surgical resection.
