Relationship between TGF-β1 509T/C Gene Polymorphism and Liver Cirrhosis: a Meta-Analysis

VernacularTitle:TGF-β1509T/C基因多态性与肝硬化相关性的Meta分析
Author: Haibin YU ; Huiguo DING
Keywords: Liver cirrhosis; Transforming growth factor beta1; Genetic polymorphism; Enetic; Meta-analysis
From: Journal of Medical Research 2017;46(7):36-40
CountryChina
Language:Chinese
Abstract: Objective To evaluate the relationship between genetic polymorphism of transforming growth factor(TGF) β1 and susceptibility of liver cirrhosis.Methods CBM,VIP,CNKI,Wanfang technological periodical full-text databases and Pubmed from set up to March,2017 were electronically searched to identify case-control studies on the relationship between genetic polymorphism of TGF-β1 promoter 509 site,and liver cirrhosis.The data were quantitatively analyzed by Stata 12.0 software after assessing the quality of included studies.Results Ten case-control studies were selected for Meta-analysis based on our inclusion and exclusion standards.The results of Meta-analysis showed that the pooled OR value for liver cirrhosis with T allele of TGF-β1 gene at promoter 509 was 1.07 (95％ CI:0.81-1.41),the pooled OR values of dominant gene model analysis (TT + CT vs CC) were 1.08 (95％ CI:0.73-1.61).No significant publication bias was found.Conlcusion The genetic polymorphism of TGF-β1 at promoter 509 showed no association with susceptibility of liver cirrhosis.