Changes in Serum Inflammatory Cytokines, Plasma Hcy and Hemorheology in Patients with Diabetic Microangiopathy
10.11969/j.issn.1673-548X.2017.07.036
- VernacularTitle:血清炎性因子、血浆Hcy和血液流变学指标在糖尿病微血管病变患者中的变化
- Author:
Junjie DONG
;
Lihong DONG
- Keywords:
Serum inflammatory cytokines;
Homocysteine;
Hemorheology;
Diabetes mellitus;
Retinopathy
- From:
Journal of Medical Research
2017;46(7):145-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes in serum inflammatory cytokines,plasma homocysteine (Hcy) and hemorheology in patients with diabetic microangiopathy of different severity.Methods A total of 180 T2DM patients admitted to our hospital from January 2013 to July 2015 were selected and randomized into either the no diabetic retinopathy (NDR) group,background diabetic retinopathy (BDR) group or proliferative diabetic retinopathy (PDR) group,each including 60 patients.We compared serum hypersensitive c-reactive protein (hs-CRP),interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels,plasma Hcy level,and hemorheological indicators across the three groups.Results Serum hs-CRP,IL-6 and TNF-α levels,plasma Hcy level and hemorheological indicators were all significantly higher in BDR and PDR groups than in NDR group,with statistically significant differences (P ＜ 0.05).Serum hs-CRP,IL-6 and TNF-αt levels,plasma Hcy level and hemorheological indicators were all significantly higher in PDR group than in BDR group,with statistically significant differences (P ＜ 0.05).Conclusion Serum hs-CRP,IL-6 and TNF-α levels,plasma Hcy level and hemorheological indicators would raise constantly with disease progression in diabetic patients,which might be associated with the development and progression of retinopathy.
