Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors.
- Author:
Laura MANDELLI
1
;
Elena TOSCANO
;
Stefano PORCELLI
;
Chiara FABBRI
;
Alessandro SERRETTI
Author Information
- Publication Type:Brief Communication
- Keywords: Schizophrenia; Age of onset; ST8SIA2; Stressful life events; Gene-environment interaction
- MeSH: Age of Onset*; Gene-Environment Interaction; Humans; Polymorphism, Single Nucleotide; Psychotic Disorders; Schizophrenia*
- From:Psychiatry Investigation 2016;13(2):247-249
- CountryRepublic of Korea
- Language:English
- Abstract: In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to stressful life events (SLEs). Eight polymorphisms (SNPs) were tested in 94 Schizophreniainpatients and 176 healthy controls. Schizophrenia patients were also evaluated for SLEs in different life periods. None of the SNPs showed association with schizophrenia. Nevertheless, when crossing genetic variants with childhood SLEs, we could observe trends of interaction with age of onset. Though several limitations, our results support a protective role of ST8SIA2 in individuals exposed to moderate childhood stress.
