Gastroesophageal Reflux Affects Sleep Quality in Snoring Obese Children.
10.5223/pghn.2016.19.1.12
- Author:
Rodrigo Strehl MACHADO
1
;
Frederick W WOODLEY
;
Beth SKAGGS
;
Carlo Di LORENZO
;
Ihuoma ENELI
;
Mark SPLAINGARD
;
Hayat MOUSA
Author Information
1. Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. rodrigo.strehl@unifesp.br
- Publication Type:Original Article
- Keywords:
Gastroesophageal reflux;
Besity;
Sleep wake disorders;
Child;
Electric impedance;
Obstructive sleep apnea
- MeSH:
Arousal;
Child*;
Cystic Fibrosis;
Electric Impedance;
Esophageal pH Monitoring;
Fundoplication;
Gastroesophageal Reflux*;
Humans;
Infant;
Polysomnography;
Sleep Apnea Syndromes;
Sleep Apnea, Obstructive;
Snoring*
- From:Pediatric Gastroenterology, Hepatology & Nutrition
2016;19(1):12-19
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study was performed to evaluate the quality of sleep in snoring obese children without obstructive sleep apnea (OSA); and to study the possible relationship between sleep interruption and gastroesophageal reflux (GER) in snoring obese children. METHODS: Study subjects included 13 snoring obese children who were referred to our sleep lab for possible sleep-disordered breathing. Patients underwent multichannel intraluminal impedance and esophageal pH monitoring with simultaneous polysomnography. Exclusion criteria included history of fundoplication, cystic fibrosis, and infants under the age of 2 years. Significant association between arousals and awakenings with previous reflux were defined by symptom-association probability using 2-minute intervals. RESULTS: Sleep efficiency ranged from 67-97% (median 81%). A total of 111 reflux episodes (90% acidic) were detected during sleep, but there were more episodes per hour during awake periods after sleep onset than during sleep (median 2.3 vs. 0.6, p=0.04). There were 279 total awakenings during the sleep study; 56 (20.1%) of them in 9 patients (69.2%) were preceded by reflux episodes (55 acid, 1 non-acid). In 5 patients (38.5%), awakenings were significantly associated with reflux. CONCLUSION: The data suggest that acid GER causes sleep interruptions in obese children who have symptoms of snoring or restless sleep and without evidence of OSA.
