Analysis of adverse drug reaction of conbercept ophthalmic injection for ocular neovascular diseases
10.13389/j.cnki.rao.2017.0172
- VernacularTitle:康柏西普眼用注射液治疗眼部新生血管性疾病出现不良反应的病例分析
- Author:
Maozhu ZHAO
;
Jie ZHANG
;
Ling WAN
;
Jie ZHONG
- Keywords:
conbercept ophthalmic injection;
adverse drug reaction;
analysis
- From:
Recent Advances in Ophthalmology
2017;37(7):677-679,683
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the adverse drug reaction of intravitreal conbercept injection for the security of conbercept injection in clinical application.Methods From 2014 to 2016,248 cases of adverse drug reaction caused by intravitreal conbercept injection were monitored by 62 medical institutions from National Center for Adverse Drug Reaction Monitoring China,and analyzed in this study.Results The adverse drug reactions caused by conbercept were mainly observed in the ophthalmology system,skin system,musculoskeletal system and cardiovascular system.The adverse drug reactions mainly occurred in the early stage of injection.Among those patients,the reported treatment results were cured in 126 cases,improved in 120 cases,unchanged in 1 case,unknown in 1 case,and no anyone died.Conclusion It should give a great attention to the serious adverse reaction that caused by conbercept injection,especially for endophthalmitis,retinal detachment and vitreous hemorrhage.The incidence of serious and newly observed adverse drug reaction should be two important portions of post-marketing safety surveillance.Moreover,the quality of adverse drug reaction reports from different medical institutions needs to be improved.Their assessment and management should be enhanced.
