Grey matter concentration revealed by voxel-based morphometry in individuals with cognitive vulnerability to depression
10.11817/j.issn.1672-7347.2017.06.012
- VernacularTitle:抑郁症认知易感者脑灰质密度的基于体素的形态测量学分析
- Author:
Shuwen YUAN
;
Hui LEI
;
Shuqiao YAO
;
Xiaocui ZHANG
- Keywords:
cognitive vulnerability to depression;
voxel-based morphometry;
grey matter density;
magnetic resonance imaging
- From:
Journal of Central South University(Medical Sciences)
2017;42(6):667-672
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the grey matter concentration in individuals with cognitive vulnerability to depression.Methods:Thirty individuals with cognitive vulnerability to depression and thirty age-and gender-matched healthy controls were enrolled in this study,and they were subjected to magnetic resonance imaging (MRI) examination.The grey matter concentration differences were compared between the two groups by using voxel-based morphometry (VBM) following MRI.Results:Individuals with cognitive vulnerability to depression showed significantly lower grey matter density in bilateral insular,left cerebellum,right supplementary motor area,and left precentral gyrus than those in the healthy controls,while the healthy controls showed significantly lower grey density in the right inferior frontal gyrus,right middle frontal gyrus,and left cuneus than those in the individuals with cognitive vulnerability to depression.Conclusion:Structural brain abnormalities in individuals with cognitive vulnerability to depression might be the neural basis for cognitive vulnerability to depression.
