Regulatory effects of taurine up-regulated gene 1 on tumorigenesis
10.3969/j.issn.1000-4718.2017.07.030
- VernacularTitle:牛磺酸上调基因1对肿瘤发生发展的调控作用
- Author:
Xingming JIANG
;
Zhidong WANG
;
Jinglin LI
;
Wangyang ZHENG
;
Zhenglong LI
;
Xinheng LI
;
Yunfu CUI
- Keywords:
Long non-coding RNA;
Taurine up-regulated gene 1;
Tumorigenesis
- From:
Chinese Journal of Pathophysiology
2017;33(7):1332-1337
- CountryChina
- Language:Chinese
-
Abstract:
It has been estimated that approximately 75% of the human genome is transcribed into RNA, 74% of which would be transcribed into non-coding RNA (ncRNA).The ncRNA can be divided into 2 major groups including small RNA and long non-coding RNA (lncRNA).There is increasing evidence that the dysregulation of lncRNA is closely associated with the occurrence and progression of many tumors.The lncRNA taurine up-regulated gene 1 (TUG1) is originally detected in a genomic screen for genes in response to taurine treatment of developing mouse retinal cells.According to research reports, dysregulation of TUG1 participates in the progression of a variety of tumors.Therefore, the regulatory effects of lncRNA TUG1 on tumorigenesis are summarized in this article.
