Expression of B and T lymphocyte attenuation factor on regulatory T cell of HIV-infected patients with different diseases progression
10.3969/j.issn.1000-484X.2017.07.020
- VernacularTitle:HIV感染者调节性T细胞表面B、T淋巴细胞衰减因子的表达研究
- Author:
Yao LI
;
Siwen HU
;
Yongjun JIANG
;
Yajing FU
;
Yali CHEN
;
Xian WU
;
Lele ZHANG
;
Linbo YIN
;
Zining ZHANG
- Keywords:
HIV;
Treg;
BTLA;
Diseases progression;
Immune activation
- From:
Chinese Journal of Immunology
2017;33(7):1053-1056,1061
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the expression of BTLA on Treg cells of HIV-infected patients and investigate the role of BTLA in HIV infection.Methods: Forty-four HIV-1-infected patients (twenty-four early HIV infection,fourteen chronic HIV-infected patients with CD4+ T counts> 200 cells/μl,AIDS patients with CD4+T counts<200 cells/μl) and nine healthy people served as normal controls were selected to detect the expression of BTLA on Treg cells by flow cytometry.The correlations between BTLA expression on Treg cells and disease progression or immune activation were studied.Results: There was a higher percentage of BTLA on Treg cells in chronic HIV patients and AIDS patients than that in early HIV infected patients(P<0.05,P<0.01),and the expression of BTLA on Treg cells in AIDS patients was higher than that in normal controls(P<0.05).The expression of BTLA on Treg cells was negatively correlated with CD4+T lymphocyte counts and positively correlated with viral load (P<0.001,P<0.01).The percentage of BTLA on Treg cells was positively correlated with CD4+CD38+T lymphocytes and CD4+HLA-DR+T lymphocytes(P<0.001,P<0.001).Conclusion: Increased BTLA expression on HIV-infected Treg cells is associated with disease progression,suggesting that it may accelerate disease progression by enhancing Treg cells inhibitory function and may provide intervention information for HIV infection in the future.
