Research on mRNA expression of leptin in different kinds of ovarian cancer
10.3969/j.issn.1000-484X.2017.07.027
- VernacularTitle:不同分型卵巢癌患者组织中瘦素mRNA表达的相关研究
- Author:
Chunjing LIU
;
Jun CHEN
;
Bing DONG
;
Xianghui LU
;
Liping LI
- Keywords:
Ovarian cancer;
Pathological types;
Leptin;
mRNA
- From:
Chinese Journal of Immunology
2017;33(7):1084-1086,1100
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mRNA differential expression and clinical effect of leptin in different kinds of ovarian cancer.Methods: 129 patients with ovarian cancer and 42 controls were collected from Jun.2015 to Jun.2016 in our hospital.We got a small tissue by ovarian biopsy guided under the ultrasonic processing,detected the total RNA,purified mRNA and analyzed the correlation of the expression of leptin in different kinds and clinical stages of ovarian cancer.Results: Compared with the control groups,the mRNA expression of leptin in each group was increased(P<0.05),and the serous adenocarcinoma group increased obviously(P<0.05).Patients with clinical stage FIGO Ⅲ was significantly higher than other stages in serous adenocarcinoma group(P<0.05).Conclusion: Leptin could express in different kinds and clinical stages of ovarian cancer,and may be a new detection index for early diagnosis of ovarian cancer.
