Changes and clinical significance of serum CA199 in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2017.07.009
- VernacularTitle:2型糖尿病患者血清胃肠道肿瘤相关抗原CA199的变化及其临床意义
- Author:
Guofeng WANG
;
Ning XU
;
Tao YANG
- Keywords:
Diabetes mellitus,type 2;
CA199 antigen;
Hemoglobin A1c;
Fasting plasma glucose;
Tumor marker;
Diabetic microvascular complications;
Risk factors
- From:
Chinese Journal of Diabetes
2017;25(7):618-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between CA199 and clinical indicators and its related factors in patients with type 2 diabetes mellitus(T2DM). Methods A total of 1224 hospitalized T2DM patients were enrolled retrospectively from the Endocrinology and metabolism department of our hospital. All the patients were divided into two groups according to CA199 level:negative group (CA199<37 U/ml) and positive group(CA199≥37 U/ml). Clinical and biochemical data were compared between the two groups. Results The level of FPG,HbA1c,UACR,and the prevalence of diabetic microvascular complications were significantly higher in CA199 positive group than in negative group[(13.12±4.58)vs(10.22±4.01)mmol/L,(10.84±2.58)% vs (8.78±2.22)%,(38.25±3.15) vs (29.09±1.02)mg/g,P<0.05]. Serum albumin level was lower in CA199 positive group than in negative group[(38.59±5.33) vs (40.13±5.63)g/L,P<0.05]. Pearson correlation analysis showed that CA199 was associated with FPG,HbA1c,and serum albumin(r=0.251,0.260,-0.082,P<0.05 or P<0.01). Multiple logistic regression analysis further found that FPG and HbA1c were the independent risk factors for CA199(β=0.793,0.975,P<0.05). Conclusion The elevated CA199 in T2DM patients correlated with poor glucose control and development of diabetic microvascular complications.
