Interhemispheric synchrony differences between multiple system atrophy (Parkinsonian type) and Parkinson's disease
10.3760/cma.j.issn.1006-7876.2017.07.004
- VernacularTitle:多系统萎缩P型与帕金森病患者静息态脑镜像同伦功能连接的差异
- Author:
Qun YAO
;
Donglin ZHU
;
Chaoyong XIAO
;
Jingping SHI
- Keywords:
Multiple system atrophy;
Parkinson disease;
Magnetic resonance imaging;
Voxel mirrored homotopic correlation
- From:
Chinese Journal of Neurology
2017;50(7):496-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the resting-state functional connectivity of the two hemispheres between multiple system atrophy (Parkinsonian type,MSA-P) and Parkinson's disease (PD).Methods A total of 25 MSA-P,29 PD patients and 29 well-matched healthy controls recruited in the Nanjing Brain Hospital Affiliated to Nanjing Medical University from June 2013 to December 2015 were scanned with resting-state functional magnetic resonance imaging for voxel mirrored homotopic correlation (VMHC) analysis.The Mini Mental State Examination,Montreal Cognitive Assessment,Frontal Assessment Battery and Unified Parkinson's Disease Rating Scale-Ⅲ (UPDRS-Ⅲ) were used to assess the clinical symptom.Then the relationship between the change of VMHC values and severity of clinical symptoms was investigated.Results Compared with healthy controls,MSA-P and PD patients both showed decreased VMHC in bilateral cerebellum posterior lobe,precuneus gyrus,middle temporal gyrus,and postcentral gyrus.Compared with PD or healthy controls,MSA-P patients exhibited lower VMHC in bilateral putamen.Significant negative correlation between VMHC values of putamen and UPDRS-Ⅲ scores was found in MSAP patients (r =-0.607,P =0.001).Conclusion These functional changes suggest that the abnormal interhemispheric synchrony probably plays an important role in pathophysiology of both MSA-P and PD,and abnormal VMHC values in putamen of MSA-P may be helpful in differentiating MSA-P from PD.
