Clinical application of chimeric antigen receptor T cells
10.3760/cma.j.issn.1006-9801.2017.07.020
- VernacularTitle:嵌合抗原受体T细胞治疗的临床应用
- Author:
Yijun DUAN
- Keywords:
Receptors,antigen,T-cell;
Leukemia;
Immunotherapy
- From:
Cancer Research and Clinic
2017;29(7):498-500
- CountryChina
- Language:Chinese
-
Abstract:
Chimeric antigen receptor (CAR) T cell shows its significant therapeutic effect in part of leukemia and lymphomas, which indicates that transgenic adoptive cellular immunotherapy may be one of the breakthroughs in treatment of solid tumors and blood diseases. The functional inhibition of CAR endogenous cells in the tumor microenvironment , molecular biology function of molecules, difficulties of CAR T cells in clinical application and the solutions , how to improve the clinical efficacy and to reduce toxic side effects for future cancer immunotherapy in clinic are reviewed in this paper.
