Chronic psychological stress and immunity
10.3969/j.issn.1000-484X.2017.07.001
- VernacularTitle:慢性心理应激与免疫
- Author:
Min ZHAO
;
Jiyan ZHANG
- Keywords:
Chronic psychological stress;
Glucocorticoid;
cAMP;
Immune effector cells;
Immune regulatory cells
- From:
Chinese Journal of Immunology
2017;33(7):961-966
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of our country,people are facing more and more psychological problems.It has been demonstrated that persistent stress and depression,which leads to continuously elevated levels of stress hormones,might eventually compromise host defenses against bacterial or viral infection while increasing the reoccurance of autoimmunity and the incidence of malignancy/metastasis.Even though the molecular mechanisms by which chronic psychological stress inhibits the effector subsets in the immune system have been partially disclosed,it remains elusive whether chronic psychological stress also affects the regulatory subsets and if yes,what are the underlying mechanisms.Here,we review the findings in this field.
