Serum Vitamin A is decreased in rheumatological diseases

VernacularTitle:风湿性疾病血清维生素A水平下降
Author: Yong CHEN ; Jianlong GUAN
Keywords: Behcet′s disease; Autoimmune; Rheumatology; Vitamin A; Retinoic acid; Epidemiology
From: Chinese Journal of Immunology 2017;33(7):1068-1071
CountryChina
Language:Chinese
Abstract: Objective:To investigate the serum Vitamin A(sVit A) levels in Behcet′s disease(BD)and other rheumatological diseases.Methods: sVit A concentration was measured in BD(including 3 subtypes of eye BD,intestinal BD,and vascular BD),rheumatoid arthritis(RA),systemic lupus erythematosus(SLE),ankylosing spondylitis(AS),primary Sjogren′s syndrome(pSS) and adult onset Still disease(AOSD)and compared with healthy controls(HC).Results: The patients enrolled in this study was according with the epidemiological features;BD patients including its subtypes of eye BD,intestinal BD,and vascular BD patients all had a lower concentration of sVit A than HC(P<0.05),no statistical differences between the subtypes;RA,SLE,AS,pSS and AOSD had a lower concentration of sVit A than HC(P<0.05).Conclusion: Decreased serum Vit A levels might account for a common pathogenesis of various rheumatic diseases.