Peripheral blood immune cells in long-term survival patients after liver transplantation
10.3760/cma.j.issn.1007-631X.2017.06.014
- VernacularTitle:长期生存的肝移植受者外周血免疫细胞分析
- Author:
Linsen YE
;
Yingcai ZHANG
;
Hui TANG
;
Jia YAO
;
Yunhao CHEN
;
Yinan DENG
;
Qi ZHANG
;
Shuhong YI
;
Hua LI
;
Yang YANG
;
Guihua CHEN
- Keywords:
Liver transplantation;
T-lymphocyte subsets;
Immune tolerance
- From:
Chinese Journal of General Surgery
2017;32(6):508-511
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the features of peripheral blood immune cells in long-term survival recipients after liver transplantation.Methods The expression of T subsets (Th1,Th2,Th17,Th22,Tregs),NK cells,NKt cells,Bregs,MDSC in long-term survival recipients (postoperative follow-up time ≥5 years,30 cases),short-term survival recipients(postoperative follow-up time ≤1 year,15 cases) and healthy control (15 cases) were determined by flowcytometry.Results Th17 cells were significantly higher in the long-term group compared with short-term group and healthy control group(P ＜0.01).Tregs in long-term group compared with short-term group were significantly higher (P ＜ 0.01),but the difference was not statistically significant compared with healthy control group (P ＞ 0.05).NK cells were significantly higher in long-term group compared with short-term group and healthy control group (P ＜ 0.01).MDSC were significantly higher in long-term group compared with short-term group and healthy control group (P ＜0.01).Conclusions Th17,Tregs,NK cells and MDSC were significantly higher in long-term survival of liver recipients,which may be related to immune tolerance.
