Rivaroxaban vs.Warfarin for the treatment of lower extremity deep vein thrombosis

VernacularTitle:利伐沙班与华法林治疗下肢深静脉血栓的临床效果对比
Author: Xiu LIU ; Yuexin CHEN ; Rong ZENG ; Yuehong ZHENG ; Bao LIU
Keywords: Vein thrombosis; Warfarin; Rivaroxaban
From: Chinese Journal of General Surgery 2017;32(6):512-515
CountryChina
Language:Chinese
Abstract: Objective To compare the clinical efficacy of Rivaroxaban and Warfarin in the treatment of lower extremity deep vein thrombosis.Methods From January to December 2015,51 patients of deep vein thrombosis of the lower limb divided into.Warfarin group (21 cases) and Rivaroxaban group (30 cases).The time of each therapy lasted for 3 months or longer.The characteristics and the change of lower limb venous patency rate in two groups of patients were analyzed to evaluate the curative effect.Results Rivaroxaban group had shorter therapy time than Warfarin group.The lower limb venous patency rate in Rivaroxaban group were higher than that in Warfarin group (85.7％ vs.60％,P ＜0.05).Ultrasonography showed partial patency in 5 mixed thrombus patients of Warfarin group,while complete patency in 2 and partial patency in 3 of Rivaroxaban group.Normalized rate in peripheral venous thrombosis patients of Rivaroxaban group were higher than Warfarin group (84％ vs.25 ％ P ＜ 0.001).Conclusions Rivaraxaban is superior to Warfarin in the complete recanalization of DVT,while safe and reliable.