Value of immunohistochemistry for determining the primary site of adenocarcinoma cells in pleural effusion cell block

VernacularTitle:免疫组织化学在胸腔积液细胞块腺癌细胞原发灶判断中的价值
Author: Xiaojuan LI ; Xiujuan LI
Keywords: Pleural effusion; Neoplasms,unknown primary; Immunohistochemistry; Liquid-based cytology
From: Cancer Research and Clinic 2017;29(7):470-473
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical significance of immunohistochemistry (IHC) for determining the primary site of adenocarcinoma cells in pleural effusion cell block. Methods One hundred and eight cases of pleural effusion diagnosed as adenocarcinoma were collected by using liquid-based cytology from January 2013 to June 2016 in Yuncheng Central Hospital. Sediment cells were gathered through centrifuging and paraffin block was made, then 94 cases were selected for IHC detection. Results Among 94 cases of adenocarcinoma diagnosed by using liquid-based cytology, 92 cases were still diagnosed as adenocarcinoma by IHC, including 70 cases of lung source, 2 cases of breast, 6 cases of ovary, 8 cases of alimentary canal, 1 case of peritoneal serouspapillary carcinoma, and 5 cases of unknown source. The other 2 cases were diagnosed as mesothelial cells and mesothelial tumors respectively. Conclusion Pleural effusion cells block and multiple IHC can improve the tumor cell detection for the judgement of the benign and malignant tumor cells and differential diagnosis to find the primary site of tumors.